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Genetics and genomics in Peru: Clinical and research perspective
(Wiley Open Access, 2018-12-25)
Acceso abierto
Peruvians currently preserve in their DNA the history of 2.5 million years of human evolution and 150,000 years of migration from Africa to Peru or the Americas. The development of Genetics and Genomics in the clinical and ...
Peruvian horse sickness virus and Yunnan orbivirus, isolated from vertebrates and mosquitoes in Peru and Australia
(Elsevier B.V., 2009-11-25)
Acceso abierto
During 1997, two new viruses were isolated from outbreaks of disease that occurred in horses, donkeys, cattle and sheep in Peru. Genome characterization showed that the virus isolated from horses (with neurological disorders, ...
A Novel Locus (RP24) for X-linked Retinitis Pigmentosa Maps to Xq26-27
(Cell Press, 1998-11)
Acceso abierto
Two genetic loci, RP2 and RP3, for X-linked retinitis pigmentosa (XLRP) have been localized to Xp11.3-11.23 and Xp21.1, respectively. RP3 appears to account for 70% of XLRP families; however, mutations in the RPGR gene ...
The current genomic landscape of western south america: andes, amazonia, and pacific coast.
(Society for Molecular Biology and Evolution, 2019-12)
Acceso abierto
Studies of Native South American genetic diversity have helped to shed light on the peopling and differentiation of the continent, but available data are sparse for the major ecogeographic domains. These include the Pacific ...
From colorectal cancer pattern to the characterization of individuals at risk: picture for genetic research in Latin America
(John Wiley & Sons Ltd, 2019-05-17)
Acceso abierto
Colorectal cancer (CRC) is one of the most common cancers in Latin America and the Caribbean, with the highest rates reported for Uruguay, Brazil and Argentina. We provide a global snapshot of the CRC patterns, how screening ...
Novel mutation in ENG gene causing Hereditary Hemorrhagic Telangiectasia in a Peruvian family
(Sociedade Brasileira de Genética, 2020)
Acceso abierto
Hereditary Hemorrhagic Telangiectasia (HHT) is a rare disorder of vascular development. Common manifestations include epistaxis, telangiectasias and arteriovenous malformations (AVMs) in multiple organs. Most patients have ...
Extreme High Prevalence of a Defective Mannose-Binding Lectin (MBL2 ) Genotype in Native South American West Andean Populations
(PLOS ONE, 2014)
Acceso abierto
Mannose-binding lectin (MBL) is one of the five recognition molecules in the lectin complement pathway. Common variant
alleles in the promoter and structural regions of the human MBL gene (MBL2) influence the stability ...
Three Novel Polymorphic Microsatellite Markers for the Glaucoma Locus GLC1B by Datamining Tetranucleotide Repeats on Chromosome 2p12-q12
(Genetics and Molecular Biology, 2009)
Acceso abierto
In order to identify new markers around the glaucoma locus GLC1B as a tool to refine its critical region at
2p11.2-2q11.2, we searched the critical region sequence obtained from the UCSC database for tetranucleotide
(GATA)n ...
Variabilidad genética de la respuesta inflamatoria. I. Polimorfismo -511 C/T en el gen IL1β en diferentes subpoblaciones peruanas
(Anales de la Facultad de Medicina, 2012)
Acceso abierto
El polimorfismo -511 citosina/timina (-511 C/T) en la región promotora del gen interleuquina 1 beta (IL1β) está implicado en la
producción diferencial de la citoquina y por tanto puede estar asociado a la respuesta ...
Optimización del test de micronúcleos en linfocitos cultivados usando una metodología de gradiente y frotis
(Revista Peruana de Biología, 2011-08-25)
Acceso abierto
El test de micronúcleos en cultivo de linfocitos es una prueba validada para estudiar mutagenicidad. Consiste
en detectar material nuclear interfásico dañado, producto de fragmentación cromosómica o errores de división
nuclear ...
